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CK-MB Test
Also known as: CK MB, CPK  
  Formally known as: Creatine 

Cardiac Markers:  
Troponin I/Troponin T

- Cardiac Troponins as
   Markers of Myocardial Injury

Cardiac Markers:  
Myoglobin Test
Common Questions

Cardiac Markers:  
CK, CPK Test
   Creatinine Kinase

Cardiac Markers:  
LD, LDH Test
    Lactate Dehydrogenase
    Ť è

 Myocardial infarction

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Reference test procedure


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  Cardiac Markers:      
Related tests: CK, Myoglobin, Troponin

Common Questions
1. What does heart attack mean?
2. If I have chest pain, does that mean I am having a heart attack? 
3. What are the other heart attack tests? 
4. What if Im not sure Im having a heart attack? 

1. What does heart attack mean?
Heart attack means that some of the muscle in your heart has died. A medical term for this is myocardial infarction (MI). Most commonly, a heart attack starts with a kind of heavy pressure or pain in the chest, often extending into the neck or left arm. You may have trouble catching your breath, or you may feel weak and break into a cold sweat. 

A heart attack usually occurs because one of the blood vessels (called coronary arteries) that bring blood to your heart muscle is blocked. This usually happens when a blood clot forms in a blood vessel that is already partially blocked. The partial blockage, which happens gradually over many years, is usually caused by too much fat layered in the wall of the blood vessel (this is often called hardening of the arteriesthe medical term for this is atherosclerosis).

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2. If I have chest pain, does that mean I am having a heart attack? 
Many other problems can cause chest pain, and it is not always possible to tell just from the type of chest pain whether or not you are having a heart attack. Many people have chest pain from straining the muscles in their chest, and chest pain can occur with some lung problems. Chest pain can be a warning sign of hardening of the arteries of the heart (coronary artery disease or CAD). Chest pain that occurs during exercise, hard work, or at times of stress, lasts for a few minutes and goes away with rest is called angina. If the pain lasts longer than just a few minutes, especially if it occurs when you are resting, seek immediate medical attention.

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3. What are the other heart attack tests? 
Doctors often use more than one test to determine if a person who has chest pain is having a heart attack. Troponin can pick up damage to heart muscles even when there is no other evidence of a heart attack. Myoglobin and creatine kinase do not usually rise in persons with heart injury unless a heart attack has occurred. Some doctors use the term mild heart attack if troponin is high but one or both of the other muscle proteins are not.

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4. What if Im not sure Im having a heart attack? 
If you have prolonged chest pain, especially if it does not go away with rest or if you have been told you have angina, and the drugs you were prescribed do not ease the painseek immediate medical attention. Many people who have had a heart attack die without ever having tried to call an ambulance or get to an emergency room.

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Why get tested?
To determine if you have had a heart attack and whether certain clot-busting drugs are working

When to get tested?
If you have chest pain and your CK levels are high

Sample required?
A blood sample drawn from a vein in the arm

The Test Sample

What is being tested?
CKMB is one of three separate forms of the enzyme creatine kinase (CK). CKMB is found mostly in heart muscle. It rises when there is any disease or damage to heart muscle cells.

How is the sample collected for testing?
A blood sample is taken by needle from the arm. 


CK-MB Test
How is it used?
When is it ordered?
What does the test result mean?
Is there anything else I should know?

How is it used?
CKMB levels, along with total CK, are tested in persons who have chest pain to diagnose whether they have had a heart attack. Since a high total CK could indicate damage to either the heart or other muscles, a high CKMB suggests that the damage was to heart muscle. If your doctor thinks you have had a heart attack and gives you a clot-busting drug (called a thrombolytic), CKMB can help your doctor tell if the drug worked. When the clot is broken open, CKMB tends to rise and fall faster. By measuring CKMB in blood several times, your doctor can usually tell whether the drug has worked.

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When is it ordered?
CK-MB is usually ordered, along with total CK, in persons with chest pain to determine whether the pain is due to a heart attack. It may also be ordered in a person with a high CK to determine whether damage is to the heart or other muscles.

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What does the test result mean?
If the ratio of CKMB to total CK (relative index) is more than 2.53, the heart is the likely muscle damaged. A high CK with a very low relative index suggests that other muscles were damaged.

In most cases, test results are reported as numerical values rather than as "high" or "low", "positive" or "negative", or "normal". In these instances, it is necessary to know the reference range for the particular test. However, reference ranges may vary by the patient's age, sex, as well as the instrumentation or kit used to perform the test. To learn more about reference ranges, please see the article, Reference Ranges and What They Mean. To learn the reference range for your test, consult your doctor or laboratorian.

Is there anything else I should know?
Severe injury to skeletal muscle can be significant enough to raise CKMB levels above normal, but such injury doesnt usually cause a high relative index. If your doctor suspects injury to both heart muscle and skeletal muscle, it may be hard to detect heart injury. Then your doctor may need to order other tests (such as troponin).


Sometimes persons who are having trouble breathing have to use their chest muscles. Chest muscles have more CKMB than other muscles, which would raise the amount of CKMB in the blood.

Persons whose kidneys have failed can also have high CKMB levels without having had a heart attack. Rarely, chronic muscle disease, low thyroid hormone levels, and alcohol abuse can increase CKMB, producing changes similar to those seen in a heart attack.

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CK - MB Kinetic Test kit
Stabilty :Dissolve contents of enzyme reagent /R2 with the corresponding volume of buffer /R1.
Gently swirl until completely dissolved.
This working reagent is stable for 15 days at + 2 to + 8C or 3 days at +20 to +25 C.
Storing Temperature :
Working Temperature :Temperature: +25 / +30 / +37C



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